Metabolic features of the period of early neonatal adaptation in premature infants from monochorionic twins
https://doi.org/10.69964/BMCC-2025-2-3-87-96
Abstract
Summary. Specific complications of monochorionic multiple pregnancy affect both the antenatal development of the fetus and the period of early neonatal adaptation, which is accompanied by metabolic status disorders.
The purpose of the study. To study metabolic parameters (according to routine indicators of biochemical blood analysis and metabolic indices) in premature infants from monochorionic twins in the period of early neonatal adaptation.
Materials and methods. The study was carried out at the Research Institute of Obstetrics and Maternity Care of the Ministry of Health of the Russian Federation from 01.01.2018 to 31.12.2024. The study included 1230 premature monochorionic diamniotic (MCDA) twins of gestational age 22/0-36/6 weeks.
Results and discussion. Differences were found between the groups of MHD twins with complicated and uncomplicated antenatal periods in the following parameters: total protein, g/l (group 1 — 41.0 (34.6-46.0); group 2 — 40.0 (36.0-46.0); group 3 — 44.0 (40.0-48.0); p<0.0001), albumin, g/l (group 1 — 29.3 (25.3-31.9); group 2 — 29.0 (27.0-31.4); group 3 — 30.1 (28.5-32.5); p<0.0001), AST U/l (group 1 — 58.0 (43.3-82.0); group 2 — 52.0 (40.0-75.0); 3rd group — 43.0 (34.0-56.0); p<0.0001), hypoglycemia (1st group — 162 (67.5%), 2nd group — 180 (65.2%), 3rd group — 396 (55.5%) p=0.002 and p=0.006, respectively), as well as a number of biochemical indices.
Conclusions. The presented assessment of the metabolic status in the group of premature MCDA twins with complicated antenatal period revealed significant changes in the studied parameters, indicating the development of neonatal dysmetabolic syndrome.
About the Authors
M. V. Pavlichenko
Federal State Budgetary Institution “Ural Research Institute of Maternity and Child Care” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Maria V. Pavlichenko - Candidate of Medical Sciences, Senior Researcher Department of Physiology and Pathology of Newborns and Young Children, Head of the Department of Children’s Rehabilitation
st. Repina, 1, Ekaterinburg, 620028
Tel.: +7 (922) 202-04-08
N. V. Kosovtsova
Federal State Budgetary Institution “Ural Research Institute of Maternity and Child Care” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Natalia V. Kosovtsova - MD, Head of the Department of Biophysical and Radiation Methods
st. Repina, 1, Ekaterinburg, 620028
Теl.: +7 (912) 26-59-169
L. A. Pestryaeva
Federal State Budgetary Institution “Ural Research Institute of Maternity and Child Care” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Pestryaeva Liudmila A. - D. in Вiology, Head of the Department of Biochemical Methods of Research
st. Repina, 1, Ekaterinburg, 620028
Теl.: +7 (906) 802-30-50
T. V. Markova
Federal State Budgetary Institution “Ural Research Institute of Maternity and Child Care” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Tatyana V. Markova - Candidate of Medical Sciences, Head of the Department of Pregnancy Pathology No. 2
st. Repina, 1, Ekaterinburg, 620028
Phone: +7 (912) 228-30-36
Ya. Yu. Pospelova
Federal State Budgetary Institution “Ural Research Institute of Maternity and Child Care” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Yana Yu. Pospelova - Candidate of Sciences, doctor of ultrasound diagnostics
st. Repina, 1, Ekaterinburg, 620028
Phone: +7 (922) 142-13-31
References
1. Volodin N.N. ed. Neonatology: National Guide. M.: GEOTAR-Media, 2023. P.752. (In Russ.)
2. Furman E.G., Nikolenko A.V., Kulizhnikov G.V. Clinical and laboratory predictors of adverse outcome in extremely premature infants. Doctor Ru. 2020; 19(10): 10-15. https://doi.org/10.31550/1727-2378-2020-19-10-10-15 (In Russ.)
3. Peck LH, Prusakov P, Mezoff EA. Biochemical Parameters in Extremely Preterm Infants Receiving Mixed Lipid Emulsions. J Pediatr Pharmacol Ther. 2021;26(8):841-849. https://doi.org/10.5863/1551-6776-26.8.841
4. Ottolini K M, N gwa J , B asu S K B rain d evelopment u sing a multicomponent intravenous lipid emulsion in preterm infants. BMC Pediatr. 2024; 24(1): 847. https://doi.org/10.1186/s12887-024-05330-9
5. D’Amato G, Brescia V, Fontana A, Biomarkers and Biochemical Indicators to Evaluate Bone Metabolism in Preterm Neonates. Biomedicines. 2024; 12(6): 1271. https://doi.org/10.3390/biomedicines12061271
6. Karsenty G, Khosla S. The crosstalk between bone remodeling and energy metabolism: A translational perspective. Cell Metab. 2022; 34(6): 805-817. https://doi.org/10.1016/j.cmet.2022.04.010
7. Casado ME, Collado-Pérez R, Frago LM, Barrios V. Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies. Int J Mol Sci. 2023; 24(2): 1422 https://doi.org/10.3390/ijms24021422
8. Vidarsdottir H, Thorkelsson T, Halldorsson TI, Bjarnason R, Geirsson RT, Rinaldo P, et al. Does metabolomic profile differ with regard to birth weight? Pediatr Res. (2020). https://doi.org/10.1038/s41390-020-1033-0
9. Torres N, Tobón-Cornejo S, Velazquez-Villegas LA, Noriega LG, Alemán-Escondrillas G, Tovar AR. Amino Acid Catabolism: An Overlooked Area of Metabolism. Nutrients. 2023; 15(15):3378. https://doi.org/10.3390/nu15153378
Review
For citations:
Pavlichenko M.V., Kosovtsova N.V., Pestryaeva L.A., Markova T.V., Pospelova Ya.Yu. Metabolic features of the period of early neonatal adaptation in premature infants from monochorionic twins. Bulletin of maternal and child care. 2025;2(3):87-96. (In Russ.) https://doi.org/10.69964/BMCC-2025-2-3-87-96
Views:
15
Email this article 