Hypoplastic endometrium in uterine infertility: modern approaches to diagnosis and treatment (literature review)
https://doi.org/10.69964/BMCC-2025-2-5-27-39
Abstract
Introduction. To date, there is no unified classification or standardized protocols for the diagnosis and treatment of uterine infertility. This is due to the heterogeneity of its causes, as well as insufficient awareness of modern methods for assessing endometrial receptivity.
Objective. To conduct a comprehensive analysis of new methods for diagnosing hypoplastic endometrium, as well as to evaluate modern approaches aimed at restoring endometrial receptive potential in women with uterine infertility.
Materials and Methods. The review includes published data from the past 10 years. A literature search was conducted in the Medline, Scopus, Web of Science, Google Scholar, PubMed, Wiley, and Cochrane Library databases. Data from 54 foreign and domestic sources were analyzed.
Results. Implantation failure associated with uterine factor infertility reduces the likelihood of natural attachment of a fertilized egg to the endometrium, which becomes a serious barrier to spontaneous conception and successful pregnancy. A fundamental factor in this process is endometrial atrophy, one of the key causes of infertility according to reproductive disorders statistics. Diagnosis of endometrial condition is critical for successful pregnancy planning in both natural cycles and ART programs, as even a high-quality embryo may fail to implant due to endometrial incompetence. Despite the accumulated experience in diagnosing and treating the problem of “thin” endometrium during the pre-pregnancy stage, this issue remains controversial and requires further scientific research.
Conclusion. Thus, achieving successful implantation and pregnancy in women with uterine infertility requires a comprehensive and multi-faceted examination to identify pathological changes in the endometrium that adversely affect its receptivity. Optimization of endometrial parameters is essential for improving reproductive outcomes and the effectiveness of assisted reproductive technology programs.
Supporting agencies: The authors declare that no funding was received for this study
About the Authors
M. A. Obryadov
Tyumen State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Mikhail A. Obryadov, Resident
Department of Obstetrics, Gynecology and Perinatology
625023; Odesskaya str., 54; Tyumen
E. Yu. Kukarskaya
State Budgetary Institution of Medical Sciences “Perinatal Center”
Russian Federation
Russian Federation
Ekaterina Yu. Kukarskaya, obstetrician-gynecologist
Gynecology Department
625002; Daudelnaya str., 1; Tyumen
A. A. Sukhanov
State Budgetary Institution of Medical Sciences “Perinatal Center”; Tyumen State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Anton A. Sukhanov, Doctor of Medical Sciences, Head of the Department, Associate Professor
Department of Gynecology; Institute of Maternity and Childhood; Department of Obstetrics and Gynecology
625002; Daudelnaya str., 1; 625023; Odesskaya str., 54; Tyumen
Phone: +7 (912) 998 07 57
A. R. Rybak
Tyumen State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Anna R. Rybak, 6th-year student
Institute of Clinical Medicine
625023; Odesskaya str., 54; Tyumen
A. A. Serebryakova
Tyumen State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Anastasia A. Serebryakova, 5th-year student
Institute of Clinical Medicine
625023; Odesskaya str., 54; Tyumen
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For citations:
Obryadov M.A., Kukarskaya E.Yu., Sukhanov A.A., Rybak A.R., Serebryakova A.A. Hypoplastic endometrium in uterine infertility: modern approaches to diagnosis and treatment (literature review). Bulletin of maternal and child care. 2025;2(5):27-39. (In Russ.) https://doi.org/10.69964/BMCC-2025-2-5-27-39
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